Generation Connect DTx Research

Our team is leading pioneering research studies on the use of mobile app technology to support personalized, therapeutic engagement for people living with dementia and their care partners.

Digital Therapeutic Development State

Our Digital Therapeutic Development State for the treatment of behavioral symptoms for Alzheimer’s Disease & Related Dementias (ADRD) & Mild Cognitive Impairment (MCI)

Ongoing Research Demonstrating Positive Outcomes for Formal Caregivers in the Home

NIA-funded study provides funding for app development and testing in the home

The GC app is the first tablet-based solution specifically designed for primary caregivers of people with Alzheimer’s and related dementias to promote activity engagement, facilitate communication between multiple stakeholders, and collect clinical outcome data.

Generation Connect was awarded a Phase 1 Small Business Innovation Research grant in the fall of 2020. The Phase 1 feasibility study demonstrates widespread utilization of the platform by family care partners and formal caregivers of people living dementia. Formal caregivers reported a range of improvements in client behaviors and in the client relationship.

Successful completion will lead to a larger Phase 2 clinical research trial to assess the efficacy of evidence-based interventions and the commercial viability of the CTC app. The clinical trial would position us to implement our go-to-market objective of commercializing the CTC solution in the home care industry as a digital therapeutic to reduce client behavioral and psychological symptoms, limit caregiver turnover, and extend the ability for people with dementia to age in place.

Specifically, a principal aim of the Phase 2 project will be to quantify the economic impact (e.g., reduced hospital or emergency department admissions, falls, and care transitions) and clinical outcomes (e.g., decreased anxiety, depression, and isolation), and to support or accelerate home care network efforts to standardize data collection around these key outcomes.

Preliminary Findings Demonstrate Efficacy in a Variety of Care Settings

Results show that the Generation Connect platform helps manage mood and enhance caregiver wellbeing.

A preliminary study analyzed by researchers at the University of Wisconsin–Madison School of Pharmacy found, care recipients with dementia that were given access to the Generation Connect platform experienced more positive moods.

Formal caregivers in care communities, nursing homes, and home care settings received training on how to utilize an early prototype of the Generation Connect app for engagement. They were asked to rate their care recipients’ moods before and after using the tablet.

Out of 1,089 engagement sessions, results revealed promising positive mood changes resulting from using music (χ2(10)=72.9; p <.001), YouTube (χ2(12)=64.5; p <.001) as the sole app, and multiple engagement strategies (χ2(2)=42.8; p <.001). Sessions that resulted in positive mood changes for people with dementia also positively influenced the caregivers’ day.

Pilot Research Study Focuses on Quality of Life for Music, Tablet Engagement in Nursing Homes

In an initial pilot study conducted in six assisted living communities (n=26 residents), the team found significant improvements in quality of life (p=.047) among older adults with dementia, and residents with high tablet engagement (>2,500 min over 3 months) showed greater improvements in quality of life as compared with low utilizers (Δ−5.90 points vs. Δ+0.43 points).